Venofer is an intravenous (IV) iron supplement that is used to treat iron deficiency anemia in adults who are unable to tolerate oral iron supplements or whose anemia has not responded to oral iron therapy. 

Iron is a vital nutrient that the body needs to function properly. It is an essential component of hemoglobin, a protein found in red blood cells that carries oxygen to the body’s cells. 

Without enough iron, the body cannot produce enough hemoglobin, which can lead to the development of iron-deficiency anemia. 

To produce enough hemoglobin, the body needs to have adequate levels of stored iron and transferrin saturation. Ferritin is a protein that stores iron in the body. It acts as a tank from which iron can be metabolized to produce hemoglobin when needed. When ferritin levels are low, it means that there is not enough stored in the body. 

Transferrin is a protein that transports iron throughout the body so that it can be used to produce hemoglobin. It is like a cab driver for iron, picking up iron from ferritin and delivering it to the cells that need it. 

If there is not enough transferrin in the body, then it will lead to iron deficiency. This is because the iron that is not transported by transferrin will not be used to produce hemoglobin, resulting in anemia. 

By providing the body additional iron, Venofer can correct anemia and prevent further decreases in hemoglobin.