What is Ruxience?

Ruxience, also known as rituximab, is a drug that is used in the treatment of certain types of cancer and autoimmune diseases. This drug is a monoclonal antibody, which means it targets specific cells in the body. 

Ruxience is approved for use in the treatment of non-Hodgkin’s lymphoma (NHL), chronic lymphocytic leukemia (CLL), rheumatoid arthritis (RA), and granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), which are types of vasculitis.

Antibodies are an integral part of the body’s immune system.  Normally, the body creates antibodies in response to an antigen, such as a protein in a germ, that has entered the body. The antibodies attach to the antigen in order to mark it for destruction by the immune system. 

When given to the patient, these monoclonal antibodies will attach to matching antigens like a key fits a lock. Since monoclonal antibodies target only specific cells, they may cause less toxicity to healthy cells. 

Ruxience works by targeting the CD20 antigen on normal cells and B-cells, then the body’s natural immune defenses are recruited to attack and kill the marked B-cells.  

In NHL and CLL, B-cells can become cancerous and multiply uncontrollably. By destroying these cancerous B-cells, Ruxience can help to slow or stop the progression of the disease. 

In RA and vasculitis, B-cells play a role in the autoimmune response that causes inflammation and tissue damage. By targeting and destroying these B-cells, Ruxience can help to reduce inflammation and slow the progression of these diseases.

Stem cells (young cells in the bone marrow that will develop into the various types of cells) do not have the CD20 antigen. This allows healthy B-cells to regenerate after treatment.  

What does Ruxience Treat?

  • Non-Hodgkins lymphoma 
  • Chronic lymphocytic leukemia
  • Rheumatoid arthritis
  • Granulomatosis with Polyangiitis (GPA)
  • Microscopic polyangiitis (MPA)

Side Effects

Side effects vary on the disease being treated, but common side effects include: 
  • Infusion- related reaction
  • Headache
  • Increased risk of infection
  • Nasopharyngitis
  • Upper respiratory tract infection
Click here for additional side effects

Infusion Duration

1-2 hours

Infusion Cycle

As prescribed by a physician 

What to Expect During Your Infusion

Before your infusion, it is important to drink plenty of water and come to your appointment hydrated. Additionally, you must alert us as soon as possible to any changes in your insurance to ensure that we are still an in-network provider for your infusion therapy.

  1. Your dedicated Infusion nurse will check your vitals and review your medical history to check for improvements or potential side effects of your infusion therapy. 
  2. Your nurse will begin your infusion and check in on you periodically during your treatment. 
  3. After your infusion, your nurse will monitor you for 30 minutes to ensure you do not have any complications or reactions to the infusion therapy. 

Why patients choose Pure to receive their Ruxience infusion

At Pure Infusion Suites®, we create an unmatched patient experience, improve healthcare outcomes and lower the cost of care.

Safe & Private Suites

  • Comfortable, private rooms with a relaxing, spa-like atmosphere
  • 55” TVs with Netflix, Wifi, drinks, snacks, meals & more

Expert Medical Staff

  • Certified FNPs & infusion nurses on-site
  • Insurance pre-authorizations & re-authorizations
  • Patient lab work

Patient Assistance

  • Co-pay assistance & other financial aid programs
  • Flexible scheduling
  • Easy & convenient parking

Patient Stories