What is Krystexxa?

Krystexxa (pegloticase) is an enzyme made to specifically target uric acid in the treatment of chronic gout. Krystexxa is used for patients that have failed to have success with other treatments.  

Uric acid is created when the body breaks down purines, a chemical compound that cells use to make DNA and RNA. Purines can also be ingested as they are found in high purine foods such as some seafood, meats, alcohol, and sweet drinks.  

In normal amounts, uric acid is passed through the urinary tract to exit the body. When the kidneys are unable to remove enough excess uric acid from the bloodstream, it results in hyperuricemia. The uric acid clumps together forming crystals. These crystals prefer to accumulate in joints, especially in the hands and feet, a condition  known as gout.  

Krystexxa is given to treat severe, treatment-refractory, chronic gout because the enzyme converts uric acid into allantoin, a water-soluble substance the body can easily excrete. This process decreases uric acid levels in the blood, and over time Krystexxa dissolves uric acid crystal buildup, relieving gout symptoms and flares.  

What does Krystexxa Treat?

  • Severe chronic gout 

Side Effects

  • Gout flare
  • Infusion reaction
  • Allergic reaction
  • Nausea 
  • Vomiting
  • Bruising
  • Chest pain
  • Sore throat
  • Constipation

Click here for additional side effects

Infusion Duration

2 hours

Infusion Cycle

Every 2 weeks

What to Expect During Your Infusion

Before your infusion, it is important to drink plenty of water and come to your appointment hydrated. Additionally, you must alert us as soon as possible to any changes in your insurance to ensure that we are still an in-network provider for your infusion therapy.

  1. Your dedicated Infusion nurse will check your vitals and review your medical history to check for improvements or potential side effects of your infusion therapy. 
  2. Your nurse will begin your infusion and check in on you periodically during your treatment. 
  3. After your infusion, your nurse will monitor you for 30 minutes to ensure you do not have any complications or reactions to the infusion therapy. 

Why patients choose Pure to receive their Krystexxa infusion

At Pure Infusion Suites®, we create an unmatched patient experience, improve healthcare outcomes and lower the cost of care.

Safe & Private Suites

  • Comfortable, private rooms with a relaxing, spa-like atmosphere
  • 55” TVs with Netflix, Wifi, drinks, snacks, meals & more

Expert Medical Staff

  • Certified FNPs & infusion nurses on-site
  • Insurance pre-authorizations & re-authorizations
  • Patient lab work

Patient Assistance

  • Co-pay assistance & other financial aid programs
  • Flexible scheduling
  • Easy & convenient parking

Patient Stories