Givlaari
What is Givlaari?
Givlaari (givosiran) is a subcutaneous injection given just under the skin that is prescribed to treat adults with acute hepatic porphyria (AHP).
AHP is a family of very rare genetic diseases that result in chronic illness with symptoms that include stomach pain, nausea and vomiting, muscle weakness, seizures, confusion, hallucinations, and skin lesions, ulcers, or erosions from sun exposure.
Due to its vague symptoms, AHP can be difficult to diagnose and is potentially fatal if not treated properly. People with AHP have an overproduction of the protein delta-aminolevulinate synthase 1 (ALAS1) in the liver. ALAS1 regulates the heme biosynthesis pathway in the liver that produces the body’s blood properties and liver functions. When ALAS1 is active, it creates the byproducts aminolaevulinic acid (ALA) and porphobilinogen (PBG), which are toxic in large quantities. When ALAS1 is not being regulated in people with AHP, it is overproduced, releasing toxic amounts of ALA and PBG into the body. ALA and PBG have been linked with AHP symptoms and flares.
Givlaari specifically targets the ALAS1 protein mRNA to decrease its production and ultimately decrease ALA and PBG release. This helps decrease AHP symptoms and flares.
What does Givlaari treat?
- Acute hepatic porphyria
Side Effects
Most Common:
- Injection site reaction; redness, pain, itching
- Nausea
Other side effects:
- Kidney and liver problems
- Increased blood homocysteine levels
- Severe allergic reactions
Click here for additional side effects
Injection Duration
15 minutes
Injection Cycle
Once per month
What to Expect During Your Injection
Before your injection, it is important to drink plenty of water and come to your appointment hydrated. Additionally, you must alert us as soon as possible to any changes in your insurance to ensure that we are still an in-network provider for your infusion therapy.
- Your dedicated Infusion nurse will check your vitals and review your medical history to check for improvements or potential side effects of your injection therapy.
- Your nurse will begin your infusion and check in on you periodically during your treatment.
- After your injection, your nurse will monitor you for 30 minutes to ensure you do not have any complications or reactions to the injection therapy.
Why patients choose Pure to receive their Givlaari injection:
At Pure Infusion Suites®, we create an unmatched patient experience, improve healthcare outcomes and lower the cost of care.
Safe & Private Suites
- Comfortable, private rooms with a relaxing, spa-like atmosphere
- 55” TVs with Netflix, Wifi, drinks, snacks, meals & more
Expert Medical Staff
- Certified FNPs & infusion nurses on-site
- Insurance pre-authorizations & re-authorizations
- Patient lab work
Patient Assistance
- Co-Pay assistance & other financial aid programs
- Flexible scheduling
- Easy & convenient parking
Patient Stories
We really have had a great experience! Great people that work there! They strive to make you as comfortable as possibly! They even ordered him lunch! My husband has definitely benefited from the treatments!
This has been such a wonderful experience for my husband and myself. We receive expert, professional care from a staff that is excellent in knowing our needs and taking such good care of us. The infusion center has all the latest and best equipment. The rooms are private, comfortable and clean. We couldn’t ask for a better setting to come to with our health and medical needs.
Pure Infusion Suites is a really awesome place! I love the privacy of your own room. The nurses and staff are so kind and knowledgeable. They even accept most insurances. They really take care of you here. I highly recommend this place!
A+ So careful and concerned for my safety. Jamie (the nurse) wanted to be certain that enough time had elapsed between my last dose of antibiotics and scheduled day of infusion and called my gastroenterologist to be sure. We waited for that confirmation and I greatly appreciated it. Beyond that, both Faith and Jamie made the infusion as pleasant an experience as possible. Also appreciated the candy and tv if I wanted it.
There was a little bit of a miscommunication in regards to preparation for our appointment. The staff went above and beyond to make sure that our experience was as positive as absolutely possible. I kept telling my son this is what truly great customer service looks like! I would highly recommend this location to anyone and will absolutely be back for our future infusions.
I am so impressed with how pure infusions is set up and how the people have treated me. I have never felt so taken care of, welcome, safe, heard, and valued as a patient and a person in a medical setting as I have at pure infusions. The staff is amazing and the environment is wonderful.
I have my infusions here and it's an amazing place. It's beautiful, with big comfy recliners and a big TV. You get blankets and treats and they order whatever you want for lunch. The nurses there are incredible, so sweet and attentive and funny. It's weird to have a difficult medication treatment and actually be excited to go.
My experience at Pure infusion was amazing. I have really have small veins and always have a hard time starting up an IV, but Heather had no problem and always got my IV started with one poke, she’s awesome. Professional and very friendly staff. I will definitely be going back for future infusions.
A kind person at the front desk to greet us and offer us snacks and/or a cold soda or water in this beautiful, clean 'suite' was the first great impression. The setting of a closed room with comfortable seating for both my mom Jorgi Schindler and I was the 2nd great impression. Our nurse Jaime, that came in was fabulous. She sat and answered all of our questions, she helped us feel very relaxed and welcomed, never rushed, and was absolutely terrific. Such a wonderful experience from beginning to end. HIGHLY recommend!
They have been amazing for my mom and they make her so comfortable during her infusions. The people there are so friendly and attentive. Their communication before, during and after the infusions is very thorough and detailed. It’s always clean and she loves the privacy she gets in the suite during her infusion. We would definitely recommend them to anyone needing infusions! Thank you Pure Infusions!
The staff is the best. I went to the wrong office but they worked around it and gave me the shot anyway. The best was I didn’t even feel the injection at all. Always a positive experience! Wonderful people!
Pure infusion make’s getting an infusion so much better. My GI doctors office has an infusion center and I refused to transfer there and said I wanted to stay with Pure. The staff and atmosphere is very nice.Additionally, the staff is way more helpful in my opinion in working with your insurance and communicating the progress of everything with you than other locations.
The folks at Pure Boise are always so nice and accommodating. They make getting an infusion honestly a great experience. I get to snuggle up in a large recliner with a blanket and all the snacks I could possibly want. Even though I usually have to work, sometimes even taking calls, everyone is so flexible and nice that it’s never a problem. I feel utterly pampered when I go to Pure Boise.
I got set up at Pure after moving to Idaho, after years of getting infusions at my home state. I'm blown away by this clinic. Private rooms, awesome accommodations, TVs if that's your thing, WiFi if you want to work remote, accessible locations right off the highway, kind and professional staff, even snacks... I was in the process of "defaulting" to local hospitals for my infusions but they took so long to get going that I actually looked around and found Pure. I asked my provider for a referral to Pure and got set up very quickly. With 3 appointments behind me and a lifetime more to go, I look forward to being a regular here for a long, long time.
Best, most comfortable and pleasant infusion experience I have ever had. The staff are amazing and professional, the infusion process is smoother and takes less time, and they have all the creature comforts (snacks, drinks, and more) to make IV infusions as pleasant of an experience as possible. Why would anyone go anywhere else?If you get IV infusions of any sort, check this place out. I'd bet money you will never go back to a hospital or other facility.
Pure Infusion in Boise is great. Real people, who treat me like a person, not a number. Very professional with infusion procedures. Very accommodating with appointments. Nice clean and comfortable rooms. Five stars!
The experience you get at Pure at the Boise location is more than expected.. the staff, I believe her name is Allison, helped me in ways more than I would have thought from a front desk check in gal ever would. She helped me with the cost of my treatment and then even asked what snacks I would like to have before I arrived, who does that these days!? Travis the nurse, was kind and gentle. I really think they were put on earth to help and be kind to people like me. I couldn't be more grateful for this center and the employees they have. Thank you!
Best customer service ever all the staff are amazing and super nice especially Allison and Travis who went above and beyond to make sure I was well taken care of! They even ordered me smash burger and gave me a luxury room while I was getting my infusion. 100% recommend Pure Infusion Suites they are truly one of the best places!
I have had infusions at two other infusion businesses in Boise. Pure Infusion Suites is superior to either of them. The staff is friendly & knowledgeable. Appointments are easy to make. The suites are very comfortable & I really like that the hallway wall is glass so they can check on you with just a glance. I would recommend them to anyone & have told my prescribing doctor how much I like them.
It’s a great environment and nice staff. They don’t answer their phones and they take a while to call you back. Their billing department will send you an extremely nondescript bill explains that you owe them but not what it’s for or why. Their scheduling department apparently doesn’t schedule properly either. They don’t even try to contact you about the bill it’s just a text. After the comfy environment you would think they would want to continue to create a great experience but that’s as far as it goes.
Pure Infusion has a great staff that is both friendly & knowledgeable. They provide care & understanding while you’re in their facility. I would recommend them to anyone.
Staff was courteous and efficient. Travis started my infusion therapy in one try. I got to relax in comfortable chair for 30 minutes, and before I knew it we were making making my appointment for my next session.
This Business is ao awesome. It is very professional and a very beautiful place to go. The people there are also very professional and nice. I would recommend this Business to anyone.
Always a comfortable and peaceful experience. I was kind of horrified when I walked in and they weren’t wearing masks since all their patients are some kind of immune compromised. They did happily put them on as soon as they realized that it was important to me and kept them on the whole time I was there.
My daughter was a previous patient here and it was such a lovely experience! We still reminisce about what great care she receive there. The personal care made the experience feel relaxed and comforting. Instead of viewing it as a medical need (although it was), we were able to see it as an afternoon together. Thank you for the excellent care you gave her. It was nice to meet the owners, shortly after opening. They were very friendly and courteous.
All of the staff were personable and focused on making sure the treatment went smoothly. Everyone went above and beyond and that was so greatly appreciated!
If you need Infusions absolutely ask your doctor to refer you to PURE. In today’s world medical care has lost its focus on Patient Care. Not because of Providers but due to the interference/dictatorship of our Current government.PURE has found a way to put patient care First!!! With knowledgeable empathetic experienced staff to Private rooms with the ambiance and amenities of a 5 star Hotel!!!A diagnoses requiring infusions is scary. I feel optimistic that my treatment requiring infusions in an environment like PURE Will smooth the road to a successful outcome for my overall health. Feeling Grateful………
After having multiple issues with another infusion service, I reached out to Pure Infusion Suites. Dana immediately returned my phone call and was immediately working to help resolve my case. The communication was excellent and Dana is a great job of explaining where things were in the process for non-medical speaking folks. From first phone call to getting my infusion was 4 days! Where I had been getting the run around for 3 weeks with the other company.When I arrived, I was introduced to Holly who was going to be giving me my infusion. Holly was great to work with. She was professional, informative, and approachable.Finally, the suites were fully decked out with whatever you may need. Drinks, snacks, wifi, TV. The chairs were amazingly comfy.I'm a huge fan and they have another loyal customer!
Staff are super nice. Make a treatment enjoyable! Nice having a private room and comfortable chair.
Just the best. Environment is extremely comfortable, chill, and the nurses are the best ever. Awesome front office staff, too. They are all great listeners, very attentive, and they only need to do one single and gentle poke to get you going. Then, you can relax the rest of the day, with lunch included. Never an arm stabbing expedition. 💜💜💜
I’ve been getting IVIG for 9 months and every time it’s been a pleasant / professional experience. The individual rooms are so comfortable … it’s like being at home with friends and wonderful care. I have been to other IV clinics and Pure Infusion is far superior! The nurses work hard but always have time for you! The welcome you receive at the front door is warm and sincere!
I came here for my IVIG treatment over 4 days. Everyone was excellent and accommodating. I had Bella as my nurse for 3 of the days and Haley for the last day; both of them were amazing. I was nervous about starting IVIG but they made the experience go as smoothly as possible and adjusted accordingly when I had some side effects. They never rushed me when I needed to go slower the last two days. The office also provided lunch for me which was a very nice surprise and had a comfortable area for my family to sit in the room while they kept me company.
Hands down the best infusion experience I’ve ever had. The facility and more importantly the nurses couldn’t be better!
Veronica was my nurse and she was great! She went above and beyond when she logged into her Peacock account so I could watch Team USA in the world cup.
If you are looking for a place to get your infusions, this is it. Natalie was my nurse and she provided exceptional patient care, and spent time getting to know me.From a customer service standpoint they are amazing as well. The girl at the front desk was so welcoming and made me feel comfortable from the start and helped me sign up for the copay program for my medication.They provide a pillow, plush blanket, a TV with streaming options, snacks, drinks and even buy you lunch. I joked with Natalie that it felt like a "white glove" or "first class experience."I think providing those options adds to the patient experience in the sense that you feel comfortable and therefore less nervous. Natalie took great care of me during and especially after my infusion to make sure I was truly good to go before leaving their care.Thank you all for a great experience. If I have to sit through infusions, at least it was with style, class, and real care!
Bella and Sam were wonderful. They were so welcoming and by far this was the best infusion experience. This was the first time at Pure Infusion and I hope to continue going there.
I’m so glad that I was referred to Pure Infusion! I have always loved being so well cared for every time I have walked through the door. You have privacy, large tv, quiet surroundings for resting, wonderful longtime staff and other amenities that make it more like home. Thank you Pure Staff and Nurses for all of your care!
Sam made me feel like family, and Bella was the best infusion nurse I have ever had. She ran the infusion in such a way that I had the fewest side effects ever! The room was private, beautiful, and comfortable. They even bought me lunch! I can’t recommend them enough.
