What is Nucala?

Nucala is a humanized monoclonal antibody that targets human Interleukin-5 (IL-5), it is indicated for add on maintenance treatment of patients 6 years and older with severe asthma with eosinophilic phenotype. 

Inflammation is an important component of asthma development. It is mediated by multiple cell types which include eosinophils, a type of white blood cell that protects the body from parasites, allergens and foreign bacteria. 

Eosinophilic inflammation can be characterized by high eosinophilic count via bloodwork. IL-5 is a major cytokine which is responsible for eosinophil development.

Nucala binds and targets IL-5 blocking. IL-5 binds to the alpha chain of the IL-5 receptor complex. This prevents IL-5 signaling, reducing the production and survival of eosinophils.

What does Nucala Treat?

  • Severe asthma and with an eosinophilic phenotype 
  • Chronic rhinosinusitis with nasal polyps (CRSwNP)
  • Eosinophilic granulomatosis with polyangiitis (EGPA) 
  • Hypereosinophilic syndrome (HES) 

Side Effects

  • Hypersensitivity reaction
  • Headache
  • Injection site reaction
  • Back pain
  • Fatigue
  • Joint pain

Click here for additional side effects

Injection Duration

5-10 minutes

Injection Cycle

Every 4 weeks

What to Expect During Your Injection

Before your infusion, it is important to drink plenty of water and come to your appointment hydrated. Additionally, you must alert us as soon as possible to any changes in your insurance to ensure that we are still an in-network provider for your infusion therapy.

  1. Your dedicated Infusion nurse will check your vitals and review your medical history to check for improvements or potential side effects of your injection therapy. 
  2. Your nurse will begin your infusion and check in on you periodically during your treatment. 
  3. After your infusion, your nurse will monitor you for 30 minutes to ensure you do not have any complications or reactions to the injection therapy. 

Why patients choose Pure to receive their Nucala injection

At Pure Infusion Suites®, we create an unmatched patient experience, improve healthcare outcomes and lower the cost of care.

Safe & Private Suites

  • Comfortable, private rooms with a relaxing, spa-like atmosphere
  • 55” TVs with Netflix, Wifi, drinks, snacks, meals & more

Expert Medical Staff

  • Certified FNPs & infusion nurses on-site
  • Insurance pre-authorizations & re-authorizations
  • Patient lab work

Patient Assistance

  • Co-pay assistance & other financial aid programs
  • Flexible scheduling
  • Easy & convenient parking

Patient Stories