What is Leqvio?

Leqvio is used to lower bad cholesterol (LDL-C) in patients suffering from atherosclerotic cardiovascular disease (ASCVD).

The liver controls lower density lipoprotein cholesterol (LDL-C) levels in the circulation by controlling the production of LDL-C and the clearance of it via the LDL receptors.

The clearance of LDL-C from the bloodstream is disrupted by PCSK9, which reduces the number of LDL receptors available to remove LDL-C from circulation.  

Leqvio is a small interfering RNA for LDL-C reduction that selectively targets the liver. After Leqvio administration, it is selectively taken up by the liver cells.

Leqvio is rapidly cleared from the bloodstream and reaches undetectable levels within 48 after administration. Leqvio is slowly released inside the cell where it loads onto the RNA induced silencing complex (RISC).

Once loaded the complex that consists of Leqvio and the body’s naturally occurring RISC successively cuts multiple copies of PCSK9 mRNA continuously, preventing its production to increase the number of LDL receptors on the surface of the liver cells, which results in greater liver acceptance of circulating LDL-C, as a result Leqvio reduces LDL-C in the bloodstream. 

What does Leqvio Treat?

  • Heterozygous familial hypercholesterolemia (HeFH) 
  • Clinical atherosclerotic cardiovascular disease (ASCVD), who require additional lowering of LDL-C 

Side Effects

  • Injection site reaction 
  • Joint pain
  • Urinary tract infection
  • Diarrhea
  • Bronchitis
  • Pain in extremities
  • Dyspnea

Click here for additional side effects

Injection Appointment Duration

5-10 minutes

Injection Cycle

The first two injections 3 months apart then every 6 months thereafter 

What to Expect During Your Injection

Before your injection, it is important to drink plenty of water and come to your appointment hydrated. Additionally, you must alert us as soon as possible to any changes in your insurance to ensure that we are still an in-network provider for your injection therapy.

  1. Your dedicated injection nurse will check your vitals and review your medical history to check for improvements or potential side effects of your infusion therapy. 
  2. Your nurse will begin your injection and check in on you periodically during your treatment. 
  3. After your injection, your nurse will monitor you for 30 minutes to ensure you do not have any complications or reactions to the infusion therapy. 

Why patients choose Pure to receive their Leqvio infusion

At Pure Infusion Suites®, we create an unmatched patient experience, improve healthcare outcomes and lower the cost of care.

Safe & Private Suites

  • Comfortable, private rooms with a relaxing, spa-like atmosphere
  • 55” TVs with Netflix, Wifi, drinks, snacks, meals & more

Expert Medical Staff

  • Certified FNPs & infusion nurses on-site
  • Insurance pre-authorizations & re-authorizations
  • Patient lab work

Patient Assistance

  • Co-pay assistance & other financial aid programs
  • Flexible scheduling
  • Easy & convenient parking

Patient Stories